Design, synthesis and antitubercular activity of compounds containing aryl and heteroaryl groups with alkylaminoethyl chains

Panda, Gautam; Parai, M K; Srivastava, A K; Chaturvedi, Vinita; Manju, Y K; Sinha, Sudhir

dc.contributor.author	Panda, Gautam
dc.contributor.author	Parai, M K
dc.contributor.author	Srivastava, A K
dc.contributor.author	Chaturvedi, Vinita
dc.contributor.author	Manju, Y K
dc.contributor.author	Sinha, Sudhir
dc.date.accessioned	2010-09-09T08:51:29Z
dc.date.available	2010-09-09T08:51:29Z
dc.date.issued	2009
dc.identifier.citation	Indian Journal of Chemistry, 48B, 2009, 1121-1127	en
dc.identifier.uri	http://hdl.handle.net/123456789/583
dc.description.abstract	Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-25 g/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on aryl and triarylmethane derivatives do not exhibit antitubercular activity. Among heteroaryl containing triarylmethanes (TRAMs), thiophene derivatives with alkylaminoethyl chain on aromatic hydroxyl group have exhibited good antitubercular activity. On the other hand, pyrrole containing TRAMs do not show good activity.	en
dc.format.extent	154958 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Tuberculosis	en
dc.subject	TB	en
dc.subject	bacterial infection	en
dc.subject	Mycobacterium tuberculosis	en
dc.subject	alkylaminoethyl chains	en
dc.subject	antitubercular activity	en
dc.subject	mycobacteria	en
dc.subject	TRAM	en
dc.title	Design, synthesis and antitubercular activity of compounds containing aryl and heteroaryl groups with alkylaminoethyl chains	en
dc.type	Article	en