Aryloxy cyclohexyl imidazoles: a novel class of antileishmanial agents

Srinivas, Nagarapu; Palne, Shraddha; Nishi; Gupta, Suman; Bhandari, Kalpana

dc.contributor.author	Srinivas, Nagarapu
dc.contributor.author	Palne, Shraddha
dc.contributor.author	Nishi
dc.contributor.author	Gupta, Suman
dc.contributor.author	Bhandari, Kalpana
dc.date.accessioned	2010-09-04T06:35:15Z
dc.date.available	2010-09-04T06:35:15Z
dc.date.issued	2009
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters,19 (2)2009,324-327	en
dc.identifier.uri	http://hdl.handle.net/123456789/581
dc.description.abstract	Thirteen novel aryloxy cyclohexane based mono and bis imidazoles were synthesized and evaluated in vitro as antileishmanials against L. donovani and cytotoxicity assessed. These compounds were better than the existing drugs, sodium stibogluconate and pentamidine in respect to IC50 and SI values. Promising compounds were tested further in-vivo. Among all, the bis methylimidazole with 2-fluoro, 4-nitro aryloxy group (9) exhibited significant in vivo inhibition of 77.9 %, thus providing new structural lead for antileishmanials.	en
dc.format.extent	126925 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Leishmania	en
dc.subject	azoles	en
dc.subject	imidazoles	en
dc.subject	aryloxy cyclohexane	en
dc.title	Aryloxy cyclohexyl imidazoles: a novel class of antileishmanial agents	en
dc.type	Article	en