Abstract:
Frequency of tuberculosis and malaria is progressively increasing worldwide. New emerging strain of bacterium and resistance to currently available drugs make this field more conscientious and alarming. In this connection a series of substituted quinolinyl chalcones and substituted quinolinyl pyrimidines were synthesised and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV and antimalarial activity against NF-54 strain of Plasmodium falciparum. A comparison of structure-activity relationship reveals that different physicochemical and structural requirements exist for these two activities. Out of synthesized compounds, compound No. 18, 19 have shown antitubercular activity of MIC 3.12 µg/ml and were non toxic against VERO, MBMDM cell lines and compounds 49, 50, 51 have shown antimalarial activity of MIC 1.0 µg/ml.
