Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials

Sunduru, Naresh; Srivastava, Kumkum; Rajakumar, S; Puri, S K; Saxena, J K; Chauhan, P M S

dc.contributor.author	Sunduru, Naresh
dc.contributor.author	Srivastava, Kumkum
dc.contributor.author	Rajakumar, S
dc.contributor.author	Puri, S K
dc.contributor.author	Saxena, J K
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2010-09-04T06:33:50Z
dc.date.available	2010-09-04T06:33:50Z
dc.date.issued	2009
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters 19(9), 2009, 2570-2573	en
dc.identifier.uri	http://hdl.handle.net/123456789/577
dc.description.abstract	In search of new 4-aminoquinolines which are not recognized by CQR mechanism, thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activity. Thiourea derivative 3 found to be the most active against CQ sensitive strain 3D7 of P. falciparum in an in vitro model with an IC50 of 6.07 ng/mL and also showed in vivo suppression of 99.27% on day 4 against CQ resistant strain N-67 of P. yoelii.	en
dc.format.extent	124671 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	4-aminoquinolines	en
dc.subject	antimalarial	en
dc.subject	P. falciparum	en
dc.subject	P. yoelii	en
dc.subject	Thiazolidinedione	en
dc.subject	Thiazolidinedione	en
dc.subject	Thioparabanic acid	en
dc.title	Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials	en
dc.type	Article	en