Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines

Sunduru, Naresh; Nishi; Palne, Shraddha; Chauhan, P M S; Gupta, Suman

dc.contributor.author	Sunduru, Naresh
dc.contributor.author	Nishi
dc.contributor.author	Palne, Shraddha
dc.contributor.author	Chauhan, P M S
dc.contributor.author	Gupta, Suman
dc.date.accessioned	2010-08-27T05:46:09Z
dc.date.available	2010-08-27T05:46:09Z
dc.date.issued	2009
dc.identifier.citation	European Journal of Medicinal Chemistry, 44, I6, 2009, 2473-2481	en
dc.identifier.uri	http://hdl.handle.net/123456789/573
dc.description.abstract	A series of 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines have been synthesized and screened for their in vitro and in vivo antileishmanial activity against L. donovani. Among all, 14 compounds have shown promising inhibition of 80-100% at 10 µg/ml against promastigotes and IC50 in the range of 0.89-9.68 µg/ml against amastigotes. Three compounds 13, 32 and 33 with good selectivity index (S.I) were screened for their in vivo activity in golden hamsters (Mesocricetus auretus) infected with MHOM/IN/80/Dd8 strain of L. donovani and have shown moderate in vivo inhibition of 48-56 % at a dose of 50 mg/Kgx5, I.P route for 5 days.	en
dc.format.extent	185610 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Leishmaniasis	en
dc.subject	pyrimidine	en
dc.subject	1,3,5-triazine	en
dc.title	Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines	en
dc.type	Article	en