Abstract:
A series of 6-tertiaryamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ones and their corresponding
heptenols, 8,9-dihydro-7H-benzocyloheptadiene[6,5-d]pyrazoles, and isoxazoles has
been prepared and tested for their pharmacological activity. It has been shown that in reduction
of 6-tertiaryamino-6,7,8;9-tetrahydro-5H-benzocyclohepten-5-.ones both the cis- and transisomers
are formed, the structure of which have been assigned on the basis of NMR studies.
6-(4-N-methylpiperazinyl) -6,7,8,9-tetrahydro-5H -benzocyclohepten-5-one has been found to
possess marked adrenolytic activity, while 6-(4-morpholinyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-
5-one and the corresponding heptenol shows central depressant action.
