Compounds Acting on the Central Nervous System. VII Studies in I-Pyridyl-4-substituted Piperazines. A A New Class of Anticonvulsants.

Abstract

A number of I-pyridyl-4-substituted piperazines have been synthesized and evaluated for their pharmacological action. A number of 1-(3-amino-4-pyridyl)-4-phenylpiperazines have been shown to possess marked anticonvulsant and antireserpine properties. Their structure-activity relationship is discussed.