Drugs Acting on CNS: Syntheses of 2-Substituted& 2,3-Disubstituted Benzo( 6,7) quinazoline-4 -ones.

GUPTA, C M; BHADURI, A P; KHANNA, K M

dc.contributor.author	GUPTA, C M
dc.contributor.author	BHADURI, A P
dc.contributor.author	KHANNA, K M
dc.date.accessioned	2010-04-29T05:22:50Z
dc.date.available	2010-04-29T05:22:50Z
dc.date.issued	1968
dc.identifier.citation	Indian journal of chemistry,6,1968,621,623.	en
dc.identifier.uri	http://hdl.handle.net/123456789/553
dc.description.abstract	A series of 2-substituted and 2,3-disubstituted benzo(6,7)quinazoline-4-ones have been synthesized as possible CNS depressants. 2-Substituted products, viz. hydrazino, phenylhydrazino and amino, have been obtained by the reaction of 2-ethylthio-benzo(6,7) quinazolin-4-one with hydrazine, phenylhydrazine, and primary and secondary amines. The 2,3-disubstituted derivatives have been obtained by the reaction of 2-mercapto-3-phenyl-benzo(6,7)quinazoline- 4-one with appropriate alkyl, arylalkyl, dialkylamino-alkyl halides in the presence of alcoholic sodium hydroxide. Some of the compounds exhibit CNS-depressant activity at high dosage.	en
dc.format.extent	1988371 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	CNS depressants	en
dc.subject	sodium hydroxide	en
dc.subject	2-Substituted	en
dc.subject	2,3-disubstituted	en
dc.title	Drugs Acting on CNS: Syntheses of 2-Substituted& 2,3-Disubstituted Benzo( 6,7) quinazoline-4 -ones.	en
dc.type	Article	en