An alternate approach to quinoline architecture via Baylis-Hillman chemistry: SnCl2-mediated tandem reaction toward synthesis of 4-(substituted vinyl)-quinolines

Madapa, Sudharshan; Singh, Virender; Batra, Sanjay

dc.contributor.author	Madapa, Sudharshan
dc.contributor.author	Singh, Virender
dc.contributor.author	Batra, Sanjay
dc.date.accessioned	2007-12-26T10:26:18Z
dc.date.available	2007-12-26T10:26:18Z
dc.date.issued	2006
dc.identifier.citation	Tetrahedron, 62, 8740 (2006)	en
dc.identifier.uri	http://hdl.handle.net/123456789/53
dc.description.abstract	An alternate approach to densely substituted quinolines from the products of SN2 nucleophilic substitution reaction between the acetyl derivatives of the Baylis-Hillman adducts obtained from 2-nitrobenzaldehydes and the carbonyl group containing carbon nucleophiles is described. Treatment of these compounds with SnCl2, trigger a tandem reaction wherein reduction of the nitro group is followed by a remarkably regioselective intramolecular cyclization and subsequent dehydrogenation to afford 4-(substituted vinyl)-quinolines.	en
dc.format.extent	232936 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication no. 6991	en
dc.subject	Quinolines	en
dc.subject	Baylis-Hillman	en
dc.subject	2-Nitrobenzaldehyde	en
dc.subject	Reduction	en
dc.subject	SnCl2	en
dc.subject	Regioselective	en
dc.title	An alternate approach to quinoline architecture via Baylis-Hillman chemistry: SnCl2-mediated tandem reaction toward synthesis of 4-(substituted vinyl)-quinolines	en
dc.type	Article	en