Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines

Mishra, A; Srivastava, K; Tripathi, R; Puri, S K; Batra, Sanjay

dc.contributor.author	Mishra, A
dc.contributor.author	Srivastava, K
dc.contributor.author	Tripathi, R
dc.contributor.author	Puri, S K
dc.contributor.author	Batra, Sanjay
dc.date.accessioned	2010-03-02T06:27:37Z
dc.date.available	2010-03-02T06:27:37Z
dc.date.issued	2009
dc.identifier.citation	European Journal of Medicinal Chemistry (2009), 44 (11), 4404-4412	en
dc.identifier.uri	http://hdl.handle.net/123456789/520
dc.description.abstract	Syntheses and in vitro antimalarial evaluation of 42 new thioureido quinazolines have been carried out. Several analogs showed promising antimalarial effect in the in vitro investigation against chloroquine-sensitive 3D7 strain of P. falciparum whereas one of the compounds shows 50% curative effect in the mouse model at an oral dose of 100mg/kg x 4 days against multi drug resistant P. yoelii nigeriensis	en
dc.format.extent	144420 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication Number 7714	en
dc.subject	antimalarial	en
dc.subject	thioureido quinazolines	en
dc.subject	chloroquine	en
dc.subject	P. falciparum	en
dc.subject	P. yoelii nigeriensis	en
dc.title	Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines	en
dc.type	Article	en