Search for new pharmacophores for antimalarial activity (Part II): Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines

Madapa, Sudharshan; Tusi, Zehra; Mishra, A; Srivastava, K; Pandey, S K; Tripathi, R; Puri, S K; Batra, Sanjay

dc.contributor.author	Madapa, Sudharshan
dc.contributor.author	Tusi, Zehra
dc.contributor.author	Mishra, A
dc.contributor.author	Srivastava, K
dc.contributor.author	Pandey, S K
dc.contributor.author	Tripathi, R
dc.contributor.author	Puri, S K
dc.contributor.author	Batra, Sanjay
dc.date.accessioned	2010-03-02T06:08:42Z
dc.date.available	2010-03-02T06:08:42Z
dc.date.issued	2009
dc.identifier.citation	Bioorganic & Medicinal Chemistry 17 (2009) 222–234	en
dc.identifier.uri	http://hdl.handle.net/123456789/519
dc.description.abstract	Synthesis of new 6-ureido-4-anilinoquinazolines have been accomplished and their in vitro antimalarial activity against chloroquine-sensitive P. falciparum have been examined. Out of 64 compounds evaluated, the IC50 of 16 compounds which have displayed MIC of 0.25 g/mL were also recorded. One of the compounds (24g) had IC50 value of 2.27 ng/mL which was equipotent to the standard drug chloroquine used in the bioassay. The in vivo evaluation of a few compounds among the series led to discovey of one analog (30g) displaying 40% curative activity (28 days) against mdr P. yoeilli nigeriensis at an oral dose of 100mg/kg x 4days	en
dc.format.extent	240861 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication Number 7626	en
dc.title	Search for new pharmacophores for antimalarial activity (Part II): Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines	en
dc.type	Article	en