Advances in the Baylis-Hillman Reaction-assisted Synthesis of Cyclic Frameworks

Abstract

Acquiring the capability to access structurally complex and diverse molecules through simple starting substrates has been one of the underlying principles of chemical research. These diverse compounds are desired in order to serve mankind in a variety of ways. They might find use in pharmaceutical, agriculture, dyes, materials, electronics and so forth. With the objective of generating an enormously complex skeletal diversity, chemists are always on the lookout for efficient complexity-generating reactions, also referred to as tandem reactions.1 These reactions may directly lead to a complex product from small and simple building blocks in a single operation or may lead to a product that is multifunctional and becomes a substrate for another complexity-generating reaction. Some of the examples of this class of reactions include the Ugi reaction, Passerini reaction, Diels-Alder reaction, ring-closing metathesis and the Baylis-Hillman reaction.