5, 6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents

Singh, F V; Parihar, Amrita; Chaurasia, Sumit; Singh, Amar B; Singh, S P; Tamrakar, A K; Srivastava, A K; Goel, Atul

dc.contributor.author	Singh, F V
dc.contributor.author	Parihar, Amrita
dc.contributor.author	Chaurasia, Sumit
dc.contributor.author	Singh, Amar B
dc.contributor.author	Singh, S P
dc.contributor.author	Tamrakar, A K
dc.contributor.author	Srivastava, A K
dc.contributor.author	Goel, Atul
dc.date.accessioned	2009-08-31T06:34:52Z
dc.date.available	2009-08-31T06:34:52Z
dc.date.issued	2009
dc.identifier.citation	Bioorg. Med. Chem. Lett.(2009) 19, 2158-2161	en
dc.identifier.uri	http://hdl.handle.net/123456789/485
dc.description.abstract	Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and alpha-glucosidase enzymes. Among various screened compounds, 5,6-diaryl substituted anthranilo-1,3-dinitriles 3a, 3b, and 3d showed good inhibitory activity against PTP-1B with IC50 values of 58-72 alphaM. Three of the test compounds showed significant (25-37%) lowering of plasma glucose level at 24 h in sucrose-challenged streptozotocin-induced diabetic Sprangue-Dawley rat model.	en
dc.format.extent	165426 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI communication number 7335	en
dc.title	5, 6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents	en
dc.type	Article	en