Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials

Misra, Mridul; Pandey, Swaroop Kumar; Pandey, Vivek Parashar; Pandey, Jyoti; Tripathi, Renu; Tripathi, R P

dc.contributor.author	Misra, Mridul
dc.contributor.author	Pandey, Swaroop Kumar
dc.contributor.author	Pandey, Vivek Parashar
dc.contributor.author	Pandey, Jyoti
dc.contributor.author	Tripathi, Renu
dc.contributor.author	Tripathi, R P
dc.date.accessioned	2009-08-31T06:34:43Z
dc.date.available	2009-08-31T06:34:43Z
dc.date.issued	2009
dc.identifier.citation	Bioorganic & Medicinal Chemistry(2009),17,625–633	en
dc.identifier.uri	http://hdl.handle.net/123456789/484
dc.description.abstract	A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of β-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against P. falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 µg /mL.	en
dc.format.extent	215008 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI communication No.7466	en
dc.subject	Tetrahydropyridines	en
dc.subject	Antimalarial activity	en
dc.subject	L-proline	en
dc.subject	Organocatalysis	en
dc.subject	Schizont maturation	en
dc.subject	Trifluoroacetic acid	en
dc.title	Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials	en
dc.type	Article	en