Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans

Dixit, Manish; Saeed, Uzma; Kumar, Amit; Siddiqi, M I; Tamrakar, A K; Srivastava, A K; Goel, Atul

dc.contributor.author	Dixit, Manish
dc.contributor.author	Saeed, Uzma
dc.contributor.author	Kumar, Amit
dc.contributor.author	Siddiqi, M I
dc.contributor.author	Tamrakar, A K
dc.contributor.author	Srivastava, A K
dc.contributor.author	Goel, Atul
dc.date.accessioned	2009-08-18T10:07:01Z
dc.date.available	2009-08-18T10:07:01Z
dc.date.issued	2008
dc.identifier.citation	Med. Chem.(2008), 4, 18-24	en
dc.identifier.uri	http://hdl.handle.net/123456789/480
dc.description.abstract	Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.	en
dc.format.extent	2488585 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 7051	en
dc.subject	Diabetes	en
dc.subject	PTP1B	en
dc.subject	4,5-dihydronaphthofuran	en
dc.subject	dibenzofuran	en
dc.subject	molecular docking	en
dc.title	Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans	en
dc.type	Article	en