Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

Batra, Sanjay; Roy, Amrendra K; Patra, A; Bhaduri, A P; Surin, W R; Raghavan, S A V; Sharma, P; Kapoor, Kapil; Dikshit, Madhu

dc.contributor.author	Batra, Sanjay
dc.contributor.author	Roy, Amrendra K
dc.contributor.author	Patra, A
dc.contributor.author	Bhaduri, A P
dc.contributor.author	Surin, W R
dc.contributor.author	Raghavan, S A V
dc.contributor.author	Sharma, P
dc.contributor.author	Kapoor, Kapil
dc.contributor.author	Dikshit, Madhu
dc.date.accessioned	2007-11-29T10:04:05Z
dc.date.available	2007-11-29T10:04:05Z
dc.date.issued	2004
dc.identifier.citation	Bioorg. Med. Chem., 12(9), 2059-2077	en
dc.identifier.uri	http://hdl.handle.net/123456789/34
dc.description.abstract	The solution phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.	en
dc.format.extent	300579 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 6468	en
dc.subject	Baylis-Hillman reaction	en
dc.subject	Isoxazolecarbaldehyde	en
dc.subject	isoxazole	en
dc.subject	nucleophilic substitution	en
dc.subject	substituted piperazine	en
dc.subject	antithrombotic activity	en
dc.subject	platelet aggregation	en
dc.title	Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents	en
dc.type	Article	en