Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines

Tripathi, R P; Saxena, Nisha; Tiwari, V K; Verma, S S; Chaturvedi, Vinita; Manju, Y K; Srivastva, A K; Gaikwad, A; Sinha, S

dc.contributor.author	Tripathi, R P
dc.contributor.author	Saxena, Nisha
dc.contributor.author	Tiwari, V K
dc.contributor.author	Verma, S S
dc.contributor.author	Chaturvedi, Vinita
dc.contributor.author	Manju, Y K
dc.contributor.author	Srivastva, A K
dc.contributor.author	Gaikwad, A
dc.contributor.author	Sinha, S
dc.date.accessioned	2009-02-10T19:22:02Z
dc.date.available	2009-02-10T19:22:02Z
dc.date.issued	2006
dc.identifier.citation	Biorganic & Med.Chem.14,8186 (2006)	en
dc.identifier.uri	http://hdl.handle.net/123456789/323
dc.description.abstract	A total of 42 benzyl-and pyridylmethyl amines were synthesized either by reductive amination of aromatic/heteroaromatic aldehydes with amines or by conjugate addition of amines to the cinnamates followed by reduction of the ester group with lithium aluminium hydride to the respective propanolamines. All the synthesized compounds were evaluated against both avirulent and virulent strains of M. tuberculosis. Many of the compounds exhibited MIC as low as 1.56 μg/ml. Few of potent compounds were also evaluated against clinical isolates of MDR TB and found to be active at one or other concentrations with MIC as low as 3.12μg /ml.	en
dc.format.extent	229293 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 7035	en
dc.subject	Tuberculosis	en
dc.subject	MDR TB	en
dc.subject	Phenylmethyl amines	en
dc.subject	Antitubercular agents	en
dc.subject	Reductive amination	en
dc.title	Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines	en
dc.type	Article	en