Leishmanicidal Activity of Phenylene Bridged  C2 Symmetric Glycosyl Ureides

Tewari, Neetu; Ramesh; Mishra, R C; Tripathi, R P; Srivastava, V M L; Gupta, Suman

dc.contributor.author	Tewari, Neetu
dc.contributor.author	Ramesh
dc.contributor.author	Mishra, R C
dc.contributor.author	Tripathi, R P
dc.contributor.author	Srivastava, V M L
dc.contributor.author	Gupta, Suman
dc.date.accessioned	2009-02-10T19:22:02Z
dc.date.available	2009-02-10T19:22:02Z
dc.date.issued	2004
dc.identifier.citation	Bioorg. Med. Chem.Lett.14, 4055 ( 2004)	en
dc.identifier.uri	http://hdl.handle.net/123456789/319
dc.description.abstract	A number of phenylene bridged C2 symmetric glycosyl uerides with ester (3a-3f), alcohol (4a-4c) and acid (5a-5d) functionalities were prepared by additon of glycosyl amino esters with phenyl diisocyantes and their further reaction with LiAlH4 or hydrolysis with LiOH. All the compounds were screened for their in vitro and in vivo antileishmanial activity. Most of the compounds exhibited good activity while two of the compounds 3e and 3f reduced the clinical dose of standard drug SSG.	en
dc.format.extent	193931 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 6524	en
dc.title	Leishmanicidal Activity of Phenylene Bridged C2 Symmetric Glycosyl Ureides	en
dc.type	Article	en