Reductive amination of glycoyl aldoses: synthesis of n-glycosylated beta-glycosyl amino alcohols and their antidiabetic potential

Verma, S S; Mishra, R C; Tamrakar, A K; Tripathi, B K; Srivastava, A K; Tripathi, R P

dc.contributor.author	Verma, S S
dc.contributor.author	Mishra, R C
dc.contributor.author	Tamrakar, A K
dc.contributor.author	Tripathi, B K
dc.contributor.author	Srivastava, A K
dc.contributor.author	Tripathi, R P
dc.date.accessioned	2009-02-10T19:22:02Z
dc.date.available	2009-02-10T19:22:02Z
dc.date.issued	2004
dc.identifier.citation	J. Carbohydr. Chem. 23, 493.( 2004)	en
dc.identifier.uri	http://hdl.handle.net/123456789/316
dc.description.abstract	Reductive amination of glycosyl aldehydes (1a-1c, 2) with glycosyl amino esters (3a-3c, 4) in presence of sodium borohydride gave diglycosylated amino esters (5-15) in good yields. N-Glycosyl-glycosylated amino esters were reduced to the respective diglycosyl amino alcohols (16-26) with LiAlH4 in good yierlds. All the synthesized compounds were studied for their inhibitory effect, if any, against hepatic glucose-6-phosphatase, glycogen phosphorylase and intestinal brush border membrane -glucosidase, among these compounds 7, 21 and 25 have shown marked inhibition on these enzymes, respectively.	en
dc.format.extent	248423 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 6605	en
dc.title	Reductive amination of glycoyl aldoses: synthesis of n-glycosylated beta-glycosyl amino alcohols and their antidiabetic potential	en
dc.type	Article	en