Diastereoselective Synthesis and Antifungal Activity of Glycosyl Isoxazolines

Mishra, R C; Tewari, Neetu; Verma, S S; Tripathi, R P; Kumar, Manish; Shukla, P K

dc.contributor.author	Mishra, R C
dc.contributor.author	Tewari, Neetu
dc.contributor.author	Verma, S S
dc.contributor.author	Tripathi, R P
dc.contributor.author	Kumar, Manish
dc.contributor.author	Shukla, P K
dc.date.accessioned	2009-02-10T19:22:02Z
dc.date.available	2009-02-10T19:22:02Z
dc.date.issued	2004
dc.identifier.citation	J. Carbohydr. Chem. 23, 353( 2004)	en
dc.identifier.uri	http://hdl.handle.net/123456789/309
dc.description.abstract	Glycosyl nitrile oxides, generated in situ by reaction of glycosyl oximes (3a, 3b, 4) with N-chlorosuccinimide and DBU, on 1,3-dipolar cycloaddition with substituted alkenes resulted in glycosyl isoxazolines (5, 7-28) in diastereoselective manner. The extent of diastereoselection varies with the nature of substituent both in sugar and alkenes. The compounds synthesized were screened in vitro against many fungi wherein two of the compounds (12, 23) showed significant inhibition against Sporothrix schenckii, Trychophyton mentegrophytes and Cryptococcus neoformans with MIC of 12.5 and 6.25 g/mL respectively.	en
dc.format.extent	196012 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No.6460	en
dc.subject	Cycloaddition	en
dc.subject	Isoxazoline	en
dc.subject	DBU	en
dc.subject	Antifungal activity	en
dc.title	Diastereoselective Synthesis and Antifungal Activity of Glycosyl Isoxazolines	en
dc.type	Article	en