Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction

Pandey, Jyoti; Dwivedi, Namrata; Srivastava, A K; Tamarkar, A; Tripathi, R P

dc.contributor.author	Pandey, Jyoti
dc.contributor.author	Dwivedi, Namrata
dc.contributor.author	Srivastava, A K
dc.contributor.author	Tamarkar, A
dc.contributor.author	Tripathi, R P
dc.date.accessioned	2009-02-10T19:21:46Z
dc.date.available	2009-02-10T19:21:46Z
dc.date.issued	2007
dc.identifier.citation	Bioorganic & Med. Chem. Letters 17, 1321 (2007)	en
dc.identifier.uri	http://hdl.handle.net/123456789/308
dc.description.abstract	1,3-Dipolar cycloaddition of azomethine ylides and glycosyl E-olefins in presence of LDA led to diastereoselective formation of C-glycosylated proline esters. The selected esters on regioselective hydrolysis with LiOH gave C-glycosyl prolines. Few of the proline esters exhibited very good α-glucosidase inhibitory activity. The organocatalytic activity of one of the prolines in a prototype Aldol reaction has also been established.	en
dc.format.extent	166390 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 7057	en
dc.title	Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction	en
dc.type	Article	en