An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanone: A New Class of Antimycobacterial Agents

Dwivedi, Namrata; Tewari, Neetu; Tiwari, V K; Chaturvedi, Vinita; Manju, Y K; Srivastava, A; Giakwad, A; Sinha, S; Tripathi, R P

dc.contributor.author	Dwivedi, Namrata
dc.contributor.author	Tewari, Neetu
dc.contributor.author	Tiwari, V K
dc.contributor.author	Chaturvedi, Vinita
dc.contributor.author	Manju, Y K
dc.contributor.author	Srivastava, A
dc.contributor.author	Giakwad, A
dc.contributor.author	Sinha, S
dc.contributor.author	Tripathi, R P
dc.date.accessioned	2009-01-08
dc.date.available	2009-01-08
dc.date.issued	2005
dc.identifier.citation	Bioorg Med Chem Lett.15, 4526-30 (2005)	en
dc.identifier.uri	http://hdl.handle.net/123456789/277
dc.description.abstract	An efficient, high yield and one pot synthesis of phenyl cyclopropyl methanones on reaction of different aryl alcohols with 4’-fluoro-4-chloro-butyrophenone in THF/DMF in presence of NaH /TBAB is reported. All the compounds were evaluated for their antitubercular activities against M. tuberculosis H37 Rv in vitro displaying MICs ranging from 25-3.125 mcg/ml. The most active compounds showed activity against MDR strains and one of them showed marginal enhancement MST in mice.	en
dc.format.extent	142409 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Tuberculosis	en
dc.subject	Tetrabutylammonium bromide	en
dc.subject	Phenyl cyclopropyl methanones	en
dc.subject	Wolf- Kishner reduction	en
dc.title	An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanone: A New Class of Antimycobacterial Agents	en
dc.type	Article	en