Abstract:
A regioselective synthesis of unsymmetrical biaryls with electron withdrawing or donating substituents is described and
illustrated by carbanion-induced ring transfonnation of 6-aryl-a-pyrones with methoxyacetone in excellent yield. Our methodology is
an alternative to classical organometal-catalyzed aryl-aryl coupling reactions and can be applied to the synthesis of functionally
demanding naphthyl biaryls for the development of new ligands for asymetric synthesis
