Recent Developments in the Side Chain Modified 4-Aminoquinolines As Antimalarial Agents

Abstract

The 4-aminoquinolines are considered to be one of the most vital synthetic antimalarial agents. However, control of malaria is threatened by inadequate resources and drug resistance particularly to this class of compounds. In order to overcome this barrier, various chemical modifications in the 4-aminoquinoline moiety have been attempted to accomplish new analogs with promising antimalarial properties against sensitive as well as resistant strains of P. falciparum with minimal undesirable side effects. This review describes essentially some of the recent advances made in the last nine years on chemical modifications of 4-aminoquinolines along with a brief description of biological evaluation. It is interesting to note that simple modifications have led to compounds having potent activity against CQ-R strains and some of these molecules are in clinical trials.