In vitro Anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives

Korthikunta, Venkateswarlu; Pandey, Jyotsana; Singh, Rohit; Srivastava, Rohit; Srivastava, A K; Tamrakar, A K; Tadigoppula, Narender

dc.contributor.author	Korthikunta, Venkateswarlu
dc.contributor.author	Pandey, Jyotsana
dc.contributor.author	Singh, Rohit
dc.contributor.author	Srivastava, Rohit
dc.contributor.author	Srivastava, A K
dc.contributor.author	Tamrakar, A K
dc.contributor.author	Tadigoppula, Narender
dc.date.accessioned	2015-05-19T11:07:23Z
dc.date.available	2015-05-19T11:07:23Z
dc.date.issued	2015
dc.identifier.citation	Phytomedicine, 2015, 22(1), 66-70	en
dc.identifier.uri	http://hdl.handle.net/123456789/1495
dc.description.abstract	The nonproteinogenic amino acid, 4-hydroxyisoleucine (1) has been isolated in large quantities from the fenugreek (T. foenum-graecum) seeds. Few novel derivatives (3-11 and 13-18) were prepared from the naturally occurring 4-hydroxyisoleucine (1) and screened for their in vitro glucose uptake stimulatory effect in L-6 skeletal muscle cells. The derivatives 6, 7, 8, 10 and 11 exhibited better glucose uptake stimulatory activity than parent compound, 4-hydroxyisoleucine at 5 and 10 µM concentrations and compounds 7 and 11 enhanced translocation of insulin sensitive glucose transporters-4 in skeletal muscle cells.	en
dc.format.extent	270738 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8817	en
dc.subject	4-hydroxyisoleucine	en
dc.subject	Fenugreek Seeds	en
dc.subject	Anti-Hyperglycemic Activity	en
dc.subject	Glucose Uptake	en
dc.subject	GLUT4 Translocation	en
dc.title	In vitro Anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives	en
dc.type	Article	en