Chemotherapy of leishmaniasis part XIII: Design and synthesis of novel heteroretinoid-bisbenzylidine ketone hybrids as antileishmanial agents

Tiwari, Avinash; Kumar, Santosh; Shivahare, Rahul; Kant, Padam; Gupta, Suman; Suryawanshi, S N

dc.contributor.author	Tiwari, Avinash
dc.contributor.author	Kumar, Santosh
dc.contributor.author	Shivahare, Rahul
dc.contributor.author	Kant, Padam
dc.contributor.author	Gupta, Suman
dc.contributor.author	Suryawanshi, S N
dc.date.accessioned	2015-05-19T08:18:46Z
dc.date.available	2015-05-19T08:18:46Z
dc.date.issued	2015
dc.identifier.citation	Bioorganic Medicinal Chemistry Letters, 2015, 25(2), 410-3	en
dc.identifier.uri	http://hdl.handle.net/123456789/1482
dc.description.abstract	Some novel heteroretinoid-bisbenzylidine ketone hybrids have been synthesized and evaluated for their in vitro antileishmanial activity against intramacrophagic amastigotes of Leishmania donovani. Among all the nine synthetic compounds, five compounds (7c, 7d and 7f-h) have shown significant (less than 7 µM) activity against intramacrophagic amastigotes. The IC50 values of these compounds were found better than the reference drugs sodium stibogluconate (SSG) and miltefosine. This study helped us in identifying the new class of compounds that could be exploited as potent antileishmanial agents	en
dc.format.extent	137379 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8811	en
dc.subject	Heteroretinoid	en
dc.subject	Bisbenzylidine ketone	en
dc.subject	Leishmania donovani	en
dc.subject	In vitro activity	en
dc.title	Chemotherapy of leishmaniasis part XIII: Design and synthesis of novel heteroretinoid-bisbenzylidine ketone hybrids as antileishmanial agents	en
dc.type	Article	en