Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity

Thakur, R K; Mishra, Akansha; Ramakrishna, K K G; Mahar, Rohit; Shukla, S K; Srivastava, A K; Tripathi, R P

dc.contributor.author	Thakur, R K
dc.contributor.author	Mishra, Akansha
dc.contributor.author	Ramakrishna, K K G
dc.contributor.author	Mahar, Rohit
dc.contributor.author	Shukla, S K
dc.contributor.author	Srivastava, A K
dc.contributor.author	Tripathi, R P
dc.date.accessioned	2015-05-13T06:30:44Z
dc.date.available	2015-05-13T06:30:44Z
dc.date.issued	2014
dc.identifier.citation	Tetrahedron, 2014, 70(45), 8462–8473	en
dc.identifier.uri	http://hdl.handle.net/123456789/1450
dc.description.abstract	A series of novel nucleoside analogues having dual bases (pyrimidine and triazole) and sugars have been synthesized by CuAAC reaction of azido sugars with propynylated pyrimidines. These compounds were evaluated for their in vitro α-glucosidase inhibitory activity. In this series, compounds 4b, 4d, 8a, 8b, 8c, 8e, 8g, 8h and 8i exhibited very good inhibition of α-glucosidase enzyme. Nucleoside analogues 8a, 4b, 8h and 8c displayed 47.4%, 41.8%, 39.4% and 34.6% inhibition respectively, comparable to the standard drug acarbose (53.4%).	en
dc.format.extent	567596 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI communication No. 8805	en
dc.subject	Pyrimidine Nucleosides	en
dc.subject	Triazoles	en
dc.subject	Azido Sugars	en
dc.subject	α-glucosidase	en
dc.title	Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity	en
dc.type	Article	en