Abstract:
A straightforward convergent synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the O-specific cell wall lipopolysaccharide of Providencia alcalifaciens O28. The target pentasaccharide has been synthesized in excellent yield using a [3+2] block glycosylation approach with minimum number of steps. Here H2SO4-silica has been used successfully as a promoter for glycosylation reaction. All glycosylation steps are high yielding and stereoselective.
