Insulin-degrading enzyme: A link between Alzheimer’s and type 2 diabetes mellitus

dc.contributor.author	Haque, Rizwanul
dc.contributor.author	Nazir, Aamir
dc.date.accessioned	2015-03-23T08:16:07Z
dc.date.available	2015-03-23T08:16:07Z
dc.date.issued	2014
dc.identifier.citation	CNS & Neurological Disorders - Drug Targets, 2014, 13(2), 259-64.	en
dc.identifier.uri	http://hdl.handle.net/123456789/1439
dc.description.abstract	Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s Disease (AD). Recent studies provide inkling for the use of IDE as a potential target, hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes and Alzheimer’s disease and the approaches, that make IDE a potential target, are discussed.	en
dc.format.extent	200242 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8881	en
dc.subject	IDE	en
dc.subject	Alzheimer’s disease	en
dc.subject	Type 2 Diabetes	en
dc.subject	Caenorhabditis elegans	en
dc.title	Insulin-degrading enzyme: A link between Alzheimer’s and type 2 diabetes mellitus	en
dc.type	Article	en