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Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity

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dc.contributor.author Reddy, P V
dc.contributor.author Saquib, Mohammad
dc.contributor.author Mishra, N N
dc.contributor.author Shukla, P K
dc.contributor.author Shaw, A K
dc.date.accessioned 2014-12-02T10:19:43Z
dc.date.available 2014-12-02T10:19:43Z
dc.date.issued 2014
dc.identifier.citation Arkivoc, 2014, 2014 (iv), 170-182 en
dc.identifier.uri http://hdl.handle.net/123456789/1421
dc.description.abstract The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various ‘in house’ synthesized sugar derived tetrahydrofuranyl azides and an adamantyl azide is described. The biological significance of the synthesized C-nucleosides was highlighted by evaluating them in vitro for anti-bacterial and anti-fungal activity wherein a number of compounds were found to show excellent anti-bacterial activity and moderate anti-fungal activity. en
dc.format.extent 1329395 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries CSIR-CDRI Communication No. 8564 en
dc.subject THF alkynes en
dc.subject THF azides en
dc.subject C-nucleosides en
dc.subject ‘click’ chemistry en
dc.subject 1,2,3-triazoles en
dc.title Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity en
dc.type Article en


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