Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity

Reddy, P V; Saquib, Mohammad; Mishra, N N; Shukla, P K; Shaw, A K

dc.contributor.author	Reddy, P V
dc.contributor.author	Saquib, Mohammad
dc.contributor.author	Mishra, N N
dc.contributor.author	Shukla, P K
dc.contributor.author	Shaw, A K
dc.date.accessioned	2014-12-02T10:19:43Z
dc.date.available	2014-12-02T10:19:43Z
dc.date.issued	2014
dc.identifier.citation	Arkivoc, 2014, 2014 (iv), 170-182	en
dc.identifier.uri	http://hdl.handle.net/123456789/1421
dc.description.abstract	The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various ‘in house’ synthesized sugar derived tetrahydrofuranyl azides and an adamantyl azide is described. The biological significance of the synthesized C-nucleosides was highlighted by evaluating them in vitro for anti-bacterial and anti-fungal activity wherein a number of compounds were found to show excellent anti-bacterial activity and moderate anti-fungal activity.	en
dc.format.extent	1329395 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8564	en
dc.subject	THF alkynes	en
dc.subject	THF azides	en
dc.subject	C-nucleosides	en
dc.subject	‘click’ chemistry	en
dc.subject	1,2,3-triazoles	en
dc.title	Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity	en
dc.type	Article	en