Efficient Stereocontrolled Synthesis of Sitagliptin Phosphate

Subbaiah, C S; Haq, W

dc.contributor.author	Subbaiah, C S
dc.contributor.author	Haq, W
dc.date.accessioned	2014-11-14T07:16:30Z
dc.date.available	2014-11-14T07:16:30Z
dc.date.issued	2014
dc.identifier.citation	Tetrahedron: Asymmetry,2014, 25(13–14), 1026–1030	en
dc.identifier.uri	http://hdl.handle.net/123456789/1420
dc.description.abstract	Synthesis of sitagliptin phosphate 1, a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from chiral synthon (1,4-bis[(R)-1-phenylethyl]piperazine-2,5-dione) 2, involving high stereocontrolled (>98%) alkylation as a key step, in a good overall yield of 50% over six steps.	en
dc.format.extent	232169 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8710	en
dc.subject	Sitagliptin phosphate	en
dc.subject	Type 2 diabetes mellitus	en
dc.subject	Stereocontrolled alkylation	en
dc.subject	Asymmetric synthesis	en
dc.title	Efficient Stereocontrolled Synthesis of Sitagliptin Phosphate	en
dc.type	Article	en