New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents

Chauhan, Kuldeep; Sharma, Moni; Trivedi, Priyanka; Chaturvedi, Vinita; Chauhan, P. M. S.

dc.contributor.author	Chauhan, Kuldeep
dc.contributor.author	Sharma, Moni
dc.contributor.author	Trivedi, Priyanka
dc.contributor.author	Chaturvedi, Vinita
dc.contributor.author	Chauhan, P. M. S.
dc.date.accessioned	2014-10-27T11:13:11Z
dc.date.available	2014-10-27T11:13:11Z
dc.date.issued	2014
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters, 2014, 24 (17), 4166–4170	en
dc.identifier.uri	http://hdl.handle.net/123456789/1419
dc.description.abstract	In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, four compounds (10, 14, 20 and 33) exhibited more potent activity (MIC = 3.08, 3.01, 2.62 and 2.51 μM) than ethambutol (MIC = 9.78 μM) and pyrazinamide (MIC = 101.53 μM) against Mycobacterium tuberculosis. Furthermore, they displayed no toxicity against Vero cells (C1008) and mouse bone marrow derived macrophages (MBMDMɸ). These investigated analogues have emerged as possible lead molecule to enlarge the scope of the study.	en
dc.format.extent	267035 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8738	en
dc.subject	Rhodanine	en
dc.subject	Tetrazole	en
dc.subject	Mycobacterium tuberculosis	en
dc.subject	Cytotoxicity	en
dc.title	New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents	en
dc.type	Article	en