Base mediated 7-exo-dig intramolecular cyclization of Ugi-Propargyl precursors: Ugi-Propargyl precursors and regioselective synthetic approach toward diverse 1, 4-benzoxazepine-5(2H)-ones

Pandey, Shashi; Kumar, S V; Kant, Ruchir; Chauhan, P M S

dc.contributor.author	Pandey, Shashi
dc.contributor.author	Kumar, S V
dc.contributor.author	Kant, Ruchir
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2014-09-17T11:10:24Z
dc.date.available	2014-09-17T11:10:24Z
dc.date.issued	2014
dc.identifier.citation	Organic & Biomolecular Chemistry, 2014, 12, 5346-5350	en
dc.identifier.uri	http://hdl.handle.net/123456789/1404
dc.description.abstract	A metal-free facile and efficient two-step synthetic protocol for the preparation of 1, 4-benzoxazepine-5(2H)-ones derivatives has been developed. The protocol involves Ugi reaction followed by K2CO3 mediated highly regioselective 7-exo-dig intramolecular cyclization of less-nucleophilic oxygen with the pendant alkyne moiety of Ugi-propargyl precursor to afford the 1, 4-benzoxazepine-5(2H)-one derivatives in good to excellent yields.	en
dc.format.extent	378725 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8711	en
dc.subject	Base Mediated 7-Exo-Dig	en
dc.subject	Intramolecular Cyclization	en
dc.subject	Ugi-Propargyl Precursors	en
dc.subject	Ugi-Propargyl Precursors	en
dc.subject	Regioselective Synthetic Approach	en
dc.title	Base mediated 7-exo-dig intramolecular cyclization of Ugi-Propargyl precursors: Ugi-Propargyl precursors and regioselective synthetic approach toward diverse 1, 4-benzoxazepine-5(2H)-ones	en
dc.type	Article	en