Synthesis of 3-Carbonyl Pyrazole-5-Phosphonates via 1,3-Dipolar Cycloaddition of Bestman-Ohira Reagent with Ynones

Pramanik, M M D; Kant, Ruchir; Rastogi, Namrata

dc.contributor.author	Pramanik, M M D
dc.contributor.author	Kant, Ruchir
dc.contributor.author	Rastogi, Namrata
dc.date.accessioned	2014-09-05T10:06:01Z
dc.date.available	2014-09-05T10:06:01Z
dc.date.issued	2014
dc.identifier.citation	Tetrahedron, 2014, 70(34): 5214–5220	en
dc.identifier.uri	http://hdl.handle.net/123456789/1391
dc.description.abstract	The present work explores the hitherto unexplored reactivity of ynones as dipolarophiles with Bestman Ohira reagent. The reaction offers a convenient route for the synthesis of regioisomerically pure 3,5-disubstituted or 3,4,5-trisubstituted pyrazoles in excellent yields. However, di-ynones and molecules possessing both ynone and enone functionalities provide only monocycloaddition products, whereas another multiple bond undergoes Michael addition with the methoxide anion.	en
dc.format.extent	249978 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 8707	en
dc.subject	Bestmann–Ohira reagent	en
dc.subject	Dipolar cycloaddition	en
dc.subject	Ynones	en
dc.subject	Phosphonyl pyrazole	en
dc.title	Synthesis of 3-Carbonyl Pyrazole-5-Phosphonates via 1,3-Dipolar Cycloaddition of Bestman-Ohira Reagent with Ynones	en
dc.type	Article	en