Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells

Chauhan, S S; Singh, A K; Meena, Sanjeev; Lohani, Minaxi; Singh, Akhilesh; Arya, R K; Cheruvu, S H; Sarkar, Jayanta; Gayen, J R; Datta, Dipak; Chauhan, P M S

dc.contributor.author	Chauhan, S S
dc.contributor.author	Singh, A K
dc.contributor.author	Meena, Sanjeev
dc.contributor.author	Lohani, Minaxi
dc.contributor.author	Singh, Akhilesh
dc.contributor.author	Arya, R K
dc.contributor.author	Cheruvu, S H
dc.contributor.author	Sarkar, Jayanta
dc.contributor.author	Gayen, J R
dc.contributor.author	Datta, Dipak
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2014-08-28T11:55:59Z
dc.date.available	2014-08-28T11:55:59Z
dc.date.issued	2014
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters, 2014, 24(13):2820-4	en
dc.identifier.uri	http://hdl.handle.net/123456789/1383
dc.description.abstract	A series of novel β-carboline based chalcones was synthesized and evaluated for their cytotoxic activity against a panel of human cancer cell lines. Among them we found that two of the compounds 7c and 7d, showed marked anti-proliferative activity in a panel of solid tumor cell lines with highest effect in breast cancer. The compounds 7c and 7d showed an IC50 of 2.25 and 3.29 µM respectively against human breast cancer MCF-7 cell line. Further, the compound 7c markedly induced DNA fragmentation and apoptosis in breast cancer cells.	en
dc.format.extent	511857 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8690	en
dc.subject	Anticancer	en
dc.subject	β-carboline	en
dc.subject	Chalcone	en
dc.subject	Cytotoxic	en
dc.title	Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells	en
dc.type	Article	en