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Now showing items 1-8 of 8

Induction of mitochondrial dysfunction and oxidative stress in Leishmania donovani by orally active clerodane diterpene

Kathuria, Manoj; Bhattacharjee, Arindam; Sashidhara, K V; Singh, S P; Mitra, Kalyan (2014)

This study was performed to investigate the mechanistic aspects of cell death induced by a clerodane diterpene (K-09) in Leishmania donovani promastigotes previously demonstrated to be safe and orally active against Visceral ...
Metabolic profiling of piper species by direct analysis in real time mass spectrometry combined with principal component analysis

Chandra, Preeti; Bajpai, Vikas; Srivastva, Mukesh; Kumar, K B R; Kumar, Brijesh (2014)

Piper nigrum (Black pepper), Piper longum (Indian tipali) and Piper chaba (Bangla tipali) are widely used medicinal herbs in traditional Indian systems of medicine. P. longum as well as P. chaba are considered as the ...
Quantitative Analysis of Bioactive Carbazole Alkaloids in Murraya koenigii

Joshi, Trapti; Mahar, Rohit; Singh, S K; Srivastava, Piush; Shukla, S K; Mishra, D K; Bhatta, R S; Kanojiya, Sanjeev (2015)

Carbazole alkaloids induce apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway and they are targeted as potential anticancer agents. Thus, the naturally occurring carbazole alkaloids become ...
A Rapid Analytical Method for Characterization and Simultaneous Quantitative Determination of Phytoconstituents in Piper betle landraces Using UPLC-ESI-MS/MS

Pandey, Renu; Chandra, Preeti; Srivastva, Mukesh; Arya, K R; Shukla, P K; Kumar, Brijesh (2014)

A rapid ultra performance liquid chromatography electrospray ionisation tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed and validated for identification and characterization of phytoconstituents with ...
Rapid profiling and structural characterization of bioactive compounds and their distribution in different parts of Berberis petiolaris Wall. ex G. Don applying hyphenated mass spectrometric techniques

Singh, Awantika; Bajpai, Vikas; Srivastava, Mukesh; Arya, KR; Kumar, Brijesh (2014)

RATIONALE: Berberis petiolaris Wall., is a lesser known medicinal plant, belonging to family Berberidaceae. Genus berberis is known for many biological activities such as anti-microbial, anti-inflammatory and anti-diarrheal ...
Rapid screening and distribution of bioactive compounds in different parts of Berberis petiolaris using direct analysis real time mass spectrometry

Singh, Awantika; Bajpai, Vikas; Srivastava, Mukesh; Arya, K R; Kumar, Brijesh (2015)

Berberis petiolaris Wall. ex G. Don, a less known medicinal plant belonging to family Berberidaceae locally known as Kingora or Kilmora is a large deciduous shrub found in Western Himalaya between 1800–3000 m. Decoction ...
Screening of tricyclic quinazoline alkaloids in the alkaloidal fraction of Adhatoda beddomei and Adhatoda vasica leaves by by high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Singh, Awantika; Kumar, Sunil; Reddy, T J; Kumar, K B R; Kumar, Brijesh (2015)

RATIONALE Adhatoda beddomei and Adhatoda vasica are popular Ayurvedic medicinal plants in India, belonging to family Acanthaceae. Tricyclic quinazoline alkaloids are found to be the most abundant in these plants which are ...
βγ-fused turn structures in sugar amino acid (SAA) containing cyclic tetrapeptides with α3δ architecture

Singh, Gajendra; Ghosh, Uttam; Pal, Sudip; Ampapathi, R S; Chakraborty, T K (2014)

The current manuscript describes conformational analysis of 15-membered cyclic tetrapeptides (CTPs), with 3 architecture, containing sugar amino acids (SAA) having variation in the stereocenter at C5 carbon. Conformational ...

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