Deoxysugars as antituberculars and alpha mannosidase inhibitors

Kashyap, Vivek; Sharma, Smriti; Singh, Vinayak; Sharma, S K; Saquib, Mohammad; Srivastava, Ranjana; Shaw, A K

dc.contributor.author	Kashyap, Vivek
dc.contributor.author	Sharma, Smriti
dc.contributor.author	Singh, Vinayak
dc.contributor.author	Sharma, S K
dc.contributor.author	Saquib, Mohammad
dc.contributor.author	Srivastava, Ranjana
dc.contributor.author	Shaw, A K
dc.date.accessioned	2014-08-11T10:44:26Z
dc.date.available	2014-08-11T10:44:26Z
dc.date.issued	2014
dc.identifier.citation	Antimicrobial Agents Chemotherapy, 2014, 58 (6), 3530-3532	en
dc.identifier.uri	http://hdl.handle.net/123456789/1355
dc.description.abstract	A promising modified sugar molecule was identified which was active against MDR strains of Mycobacterium tuberculosis suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice and targeted α-mannosidase as a competitive inhibitor with Ki value of 353.9 µM.	en
dc.format.extent	196255 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8647	en
dc.subject	Drug Development	en
dc.subject	Mycobactericidal	en
dc.subject	Alpha Mannosidase Inhibitor	en
dc.title	Deoxysugars as antituberculars and alpha mannosidase inhibitors	en
dc.type	Article	en