Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antipasmodial and antimicrobial agents

Mishra, Amita; Batchu, Harikrishna; Srivastava, Kumkum; Singh, Pratiksha; Shukla, P K; Batra, Sanjay

dc.contributor.author	Mishra, Amita
dc.contributor.author	Batchu, Harikrishna
dc.contributor.author	Srivastava, Kumkum
dc.contributor.author	Singh, Pratiksha
dc.contributor.author	Shukla, P K
dc.contributor.author	Batra, Sanjay
dc.date.accessioned	2014-08-04T11:19:35Z
dc.date.available	2014-08-04T11:19:35Z
dc.date.issued	2014
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters, 2014, 24(7), 1719-23	en
dc.identifier.uri	http://hdl.handle.net/123456789/1338
dc.description.abstract	Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of P. falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.	en
dc.format.extent	407430 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8620	en
dc.subject	Diaryl ether	en
dc.subject	Quinoline	en
dc.subject	Hybrid	en
dc.subject	Malaria	en
dc.subject	Antibacterial	en
dc.title	Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antipasmodial and antimicrobial agents	en
dc.type	Article	en