Intramolecular 5-endo-Trig Aminopalladation of β-hydroxy-γ-alkenylamine: Efficient Route to a Pyrrolidine Ring and Its Application for the Synthesis of (-)-8,8a-di-epi-swainsonine

Singh, Priyanka; Panda, Gautam

dc.contributor.author	Singh, Priyanka
dc.contributor.author	Panda, Gautam
dc.date.accessioned	2014-07-31T04:26:30Z
dc.date.available	2014-07-31T04:26:30Z
dc.date.issued	2014
dc.identifier.citation	RSC Advances, 2014, 4, 2161-2166	en
dc.identifier.uri	http://hdl.handle.net/123456789/1322
dc.description.abstract	The intramolecular aminopalladation reaction of L-serine derived β-hydroxy--alkenylamines undergoes 5-endo-trig cyclization to furnish pyrrolidine rings in high yields. The pyrrolidine thus obtained were elaborated to the synthesis of (-)-8,8a-di-epi-swainsonine, a specific and competitive inhibitor (Ki value 2 × 10-6 M) of lysosomal α-mannosidases.	en
dc.format.extent	286860 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8569	en
dc.subject	Aminopalladation	en
dc.subject	β-hydroxy-γ-alkenylamine	en
dc.subject	Pyrrolidine Ring	en
dc.subject	8a-di-epi-swainsonine	en
dc.title	Intramolecular 5-endo-Trig Aminopalladation of β-hydroxy-γ-alkenylamine: Efficient Route to a Pyrrolidine Ring and Its Application for the Synthesis of (-)-8,8a-di-epi-swainsonine	en
dc.type	Article	en