‘Chiron’ approach to the total synthesis of macrolide (+)-Aspicilin

Saidhareddy, Puli; Ajay, Sama; Shaw, A K

dc.contributor.author	Saidhareddy, Puli
dc.contributor.author	Ajay, Sama
dc.contributor.author	Shaw, A K
dc.date.accessioned	2014-07-30T06:50:38Z
dc.date.available	2014-07-30T06:50:38Z
dc.date.issued	2014
dc.identifier.citation	RSC Advances, 2014, 4, 4253-4259	en
dc.identifier.uri	http://hdl.handle.net/123456789/1319
dc.description.abstract	An efficient total synthesis of 18 membered macrolactone, (+)-Aspicilin (lichen macrolide) has been achieved in 12 linear steps and 10.2% overall yield from carbohydrate based building block D-glucal. Highlights of the strategy include preparation of 2-deoxysugar from protected glycal 14, two-carbon Wittig olefination of the Swern oxidised intermediate 7, union of ‘carbohydrate based’ fragment 5 and a long chain (C-11) chiral alcohol 6 by Yamaguchi esterification and finally ring closing metathesis of resulting compound 4.	en
dc.format.extent	227305 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8560	en
dc.subject	Chiron	en
dc.subject	Macrolide	en
dc.subject	Aspicilin	en
dc.title	‘Chiron’ approach to the total synthesis of macrolide (+)-Aspicilin	en
dc.type	Article	en