Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents*

Sashidhara, K V; Dodda, R P; Sonkar, Ravi; Palnati, G P; Bhatia, Gitika

dc.contributor.author	Sashidhara, K V
dc.contributor.author	Dodda, R P
dc.contributor.author	Sonkar, Ravi
dc.contributor.author	Palnati, G P
dc.contributor.author	Bhatia, Gitika
dc.date.accessioned	2014-07-16T09:32:24Z
dc.date.available	2014-07-16T09:32:24Z
dc.date.issued	2014
dc.identifier.citation	European Journal of Medicinal Chemistry, 2014, 81, 499 -509	en
dc.identifier.uri	http://hdl.handle.net/123456789/1309
dc.description.abstract	A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents.	en
dc.format.extent	753890 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI communication no. 8661	en
dc.subject	Indole-Chalcone Fibrates	en
dc.subject	Antidyslipidemic Activity	en
dc.subject	Triton Model	en
dc.subject	LPL Activity	en
dc.subject	Antioxidant Activity	en
dc.title	Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents*	en
dc.type	Article	en