Triazino indole-Quinoline hybrid: A novel approach to Antileishmanial agents

Sharma, Rashmi; Pandey, A K; Shivahare, Rahul; Srivastava, Khushboo; Gupta, Suman; Chauhan, P M S

dc.contributor.author	Sharma, Rashmi
dc.contributor.author	Pandey, A K
dc.contributor.author	Shivahare, Rahul
dc.contributor.author	Srivastava, Khushboo
dc.contributor.author	Gupta, Suman
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2014-05-19T06:36:15Z
dc.date.available	2014-05-19T06:36:15Z
dc.date.issued	2014
dc.identifier.citation	Bioorganic Medicinal Chemistry Letters 2014, 24, 298–301	en
dc.identifier.uri	http://hdl.handle.net/123456789/1243
dc.description.abstract	A novel series of 1,2,4-triazino-[5,6b]indole-3-thione covalently linked to 7-chloro-4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular amastigote form of Leishmania donovani. Among all tested compounds, compound 7a and 7b was found to be the most active with IC50 values 1.11, 0.36 μM and selectivity index (SI) values 67, >1111 respectively against amastigote form of L. donovani which is several folds more potent than the standard drugs, miltefosine (IC50 = 8.10 µM, SI = 7) and sodium stibo-gluconate (IC50 = 54.60 µM, SI = >7).	en
dc.format.extent	136333 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI communication no. 8565	en
dc.subject	Antileishmanial	en
dc.subject	Hybrid	en
dc.subject	In vitro	en
dc.subject	Leishmania donovani	en
dc.subject	Quinoline	en
dc.subject	Triazino-indole	en
dc.title	Triazino indole-Quinoline hybrid: A novel approach to Antileishmanial agents	en
dc.type	Article	en