Abstract:
Phenanthridines, pyrazole[4,3-c]quinolines and isocryptolepine are prepared in one-step from Pd/ Cu-catalyzed reaction between potassium 2-aminobenzoates and 2-haloarylaldehydes. Whereas the reactions of 2-aminobenzoates proceed via a cascade imination/ C-H functionalization, the reactions of 6-nitro-2-aminobenzoate ensues via tandem imination/ decarboxylative cross-coupling. Both sequences can be achieved with low catalyst loading and works over a broad substrate base.
