Lymphatic filariasis, an infectious disease caused by Wuchereria bancrofti, Brugia malayi and Brugia timori (lymph-dwelling nematode), is transmitted by mosquitoes. About 1.3 billion people living in tropical and subtropical ...

Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis (TB) and a major cause of death worldwide (Murray et al., 1990; Raviglione et al., 1995). Mtb was discovered by Robert Koch in 1882, earlier it was ...

Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone micro architecture is deteriorating, and the amount and variety of proteins ...

The role played by modern organic synthesis in the pharmaceutical industry sustains to be one of the main drivers in the drug discovery process. The problem of the limited availability of natural products in bio-evaluation ...

Flavonoids are polyphenolic compounds present in our daily dietary sources. Apigenin, Genistein and Quercetin belong to this group and have been used as dietary supplement worldwide. Indiscriminate use of flavonoids by ...

The second half of last century has witnessed an enormous and iterative progress in organic synthesis. Consequently the advent of inventive concepts with high conventional power and the development of new strategies and ...

Lymphatic filariasis (LF), one of the major causes of chronic disability in the developing countries produces a considerable economic burden. Globally, around 1100 million people in 80 countries are at risk and 118 million ...

The work reported in the thesis mainly concerns the structural and biochemical studies involving the M. tuberculosis NAD+-dependent DNA ligaseA (MtuLigA) and its potential partner proteins like the Beta clamp (Mtu -clamp) ...

Cerebral ischemia is one of the major cerebrovascular disorders which rank third in terms of death and disability among all the disorders encountered by human beings world over. Despite this tremendous burden we have not ...