Synthesis of Substituted 3-Iodocoumarins and 3-Iodobutenolides via Electrophilic Iodocyclization of  Ethoxyalkyne Diols

Reddy, M S; Thirupathi, Nuligonda; Babu, M H; Puri, Surendra

dc.contributor.author	Reddy, M S
dc.contributor.author	Thirupathi, Nuligonda
dc.contributor.author	Babu, M H
dc.contributor.author	Puri, Surendra
dc.date.accessioned	2013-07-05T10:20:46Z
dc.date.available	2013-07-05T10:20:46Z
dc.date.issued	2013
dc.identifier.citation	The Journal of Organic Chemistry, 2013, 78 (12), 5878–5888	en
dc.identifier.uri	http://hdl.handle.net/123456789/1082
dc.description.abstract	A convenient and general synthesis of various 4-substituted-3-iodocoumarins and 4,5-disubstituted-3-iodobutenolides is described via an exclusive 6-endo-dig-iodocyclization of 3-ethoxy-1-(2-alkoxyphenyl)-1-ols and 5-endo-dig-iodocyclization of 1-alkoxy-4-ethoxy-3-yn-1,2-diols respectively. The reaction is carried out in very mild conditions using I2 in CH2Cl2 or toluene at room temperature. Oxygen in OMe and OMOM groups were used as efficient nucleophiles for this intramolecular cyclization to obtain the products in good to excellent yields.	en
dc.format.extent	513238 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No: 8462	en
dc.subject	2-alkoxyphenyl	en
dc.subject	Synthesis	en
dc.title	Synthesis of Substituted 3-Iodocoumarins and 3-Iodobutenolides via Electrophilic Iodocyclization of Ethoxyalkyne Diols	en
dc.type	Article	en