Regioselective synthesis of densely functionalized, enantiopure, sugar-pyrazole hybrids as potential scaffolds for drug discovery

Saquib, Mohammad; Husain, Irfan; Kant, Ruchir; Meena, Sanjeev; Gauniyal, H M; Sinha, Sudhir; Maulik, P R; Shaw, A K

dc.contributor.author	Saquib, Mohammad
dc.contributor.author	Husain, Irfan
dc.contributor.author	Kant, Ruchir
dc.contributor.author	Meena, Sanjeev
dc.contributor.author	Gauniyal, H M
dc.contributor.author	Sinha, Sudhir
dc.contributor.author	Maulik, P R
dc.contributor.author	Shaw, A K
dc.date.accessioned	2013-04-04T11:08:43Z
dc.date.available	2013-04-04T11:08:43Z
dc.date.issued	2013
dc.identifier.citation	RSC Advances, 2013, 3, 4526-4530	en
dc.identifier.uri	http://hdl.handle.net/123456789/1040
dc.description.abstract	A versatile new synthetic strategy utilizing MBH chemistry for the assembly of highly functionalized enantiopure sugar-pyrazole hybrid molecules with multiple sites for structural diversification and non-flat skeleton as potential drug scaffolds is reported. Four representative molecules were screened for in vitro anti-cancer activity wherein three of them were found to exhibit good anti-cancer activity.	en
dc.format.extent	364385 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 8292	en
dc.subject	MBH	en
dc.subject	Sugar-pyrazole	en
dc.subject	Non-flat skeleton	en
dc.title	Regioselective synthesis of densely functionalized, enantiopure, sugar-pyrazole hybrids as potential scaffolds for drug discovery	en
dc.type	Article	en