Synthesis of Perspicamide A and Related Diverse Analogues: Their Bio-evaluation as Potent Antileishmanial Agents

Pandey, A K; Sharma, Rashmi; Shivahare, Rahul; Arora, Ashish; Rastogi, Neeraj; Gupta, Suman; Chauhan, P M S

dc.contributor.author	Pandey, A K
dc.contributor.author	Sharma, Rashmi
dc.contributor.author	Shivahare, Rahul
dc.contributor.author	Arora, Ashish
dc.contributor.author	Rastogi, Neeraj
dc.contributor.author	Gupta, Suman
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2013-04-04T11:04:06Z
dc.date.available	2013-04-04T11:04:06Z
dc.date.issued	2013
dc.identifier.citation	Journal of Organic Chemistry, 2013, 78 (4), 1534–1546	en
dc.identifier.uri	http://hdl.handle.net/123456789/1039
dc.description.abstract	The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues 24a, 24b, 24c, 24d and 24l exhibited potent activity against Leishmania donovani with IC50 values ranging from 3.75 to 10.37 µM and a selectivity index (SI) ranging from 9.58 to 53.12 which is better compared to the standard drug Miltefosine (IC50 12.4 µM and SI 4.1).	en
dc.format.extent	320531 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI communication no. 8378	en
dc.subject	Perspicamide A	en
dc.subject	Leishmania donovani	en
dc.subject	Standard drug Miltefosine	en
dc.title	Synthesis of Perspicamide A and Related Diverse Analogues: Their Bio-evaluation as Potent Antileishmanial Agents	en
dc.type	Article	en