Stabilization of Vitamins in Pharmaceutical Preparations: Part l-lnfluence of Common Vehicles on the stability of Vitamins A, B1 & C

Abstract

The stabilities afforded by different combinations of bases like sugar syrup, propylene glycol, glycerol, sorbitol, etc., to vitamins A, B, and C at 37°C. have been studied. Sorbitol-propylene glycol-glycerol-ethyl alcohol (2: 1 :'1 : 1), syrup-glycerol-water (2: 2: 1) and syrup-glycerol (1: 1) combinations retain 70 per cent of vitamin A, 73 per cent of vitamin B, and 51 per cent of vitamin C respectively during five months of storage, Vitamin C keeps well in the presence of vitamins A and B, in syrup-water (85: 15) and syrup-propylene glycol (1: 1). Syrup-glycerul-water (2: 2: 1) gives the best stability to a preparation containing vitamins A, B, and C. In general, sugar syrup affords considerable stability to all the three vitamins in different combinations with other vehicles.