Novel piperazine-derived conformationally constrained compounds were designed, synthesized, and evaluated for in vitro Dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. From a library of compounds synthesized, ...

Background: Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant of great medicinal value; used in many clinically proven conditions. NMITLI-118R a candidate drug under a CSIR networking project is a chemotype ...

Alstonia scholaris (L.) R. Br., belonging to the family Apocynaceae, is a rich source of indole alkaloids among which echitamine is the most important. It is reported as an antiproliferative agent and targeted for cancer ...

This study was performed to investigate the mechanistic aspects of cell death induced by a clerodane diterpene (K-09) in Leishmania donovani promastigotes previously demonstrated to be safe and orally active against Visceral ...

In this work, we demonstrated insulin signaling and the anti-inflammatory effects by the chloroform fraction of ethanolic extract of Nymphaea rubra flowers in TNF-α induced insulin resistance in the rat skeletal muscle ...

Microwave assisted one-pot transformation has been developed for the synthesis of biologically significant poly-substituted furoquinoxalines in good to excellent yields through a copper (II) catalyzed three-component ...

A series of amine substituted 3-phenyl coumarin derivatives were designed and synthesized as potential antidepressant agents. In preliminary screening, all compounds were evaluated in forced swimming test (FST), a model ...

The 4-aminoquinolines are considered to be one of the most vital synthetic antimalarial agents. However, control of malaria is threatened by inadequate resources and drug resistance particularly to this class of compounds. ...

PhI(OAc)2-BF3-OEt2 mediated domino synthesis of biologically important fluorenones, xanthones and phenanthridines has been developed. The reaction proceeds through imine activation, intramolecular C-C bond formation and ...

A new series of 2 (alkoxy(hydroxy)phosphoryloxy)ethyl dialkylcarbodithioate derivatives was synthesized and evaluated against endocrine related cancers, acting via modulation of Akt-pathway. Eighteen compounds were active ...