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Now showing items 101-120 of 1288

Design and Synthesis of Substituted morpholin/piperidin-1-yl-carbamodithioates as promising Vaginal Microbicides with Spermicidal potential

Bala, Veenu; Jangir, Santosh; Kumar, Vikas; Mandalapu, Dhanaraju; Gupta, Sonal; Kumar, Lalit; Kushwaha, Bhavana; Chhonker, Y S; Krishna, Atul; Maikhuri, J P; Shukla, P K; Bhatta, R S; Gupta, Gopal; Sharma, V L (2014)

A series of seventeen morpholin/piperidin-1-yl-carbamodithioate (3-19) were synthesized as topical vaginal microbicidal spermicides. The synthesized compounds were evaluated for their anti-Trichomonas activity against ...
Chitosan Assisted Immunotherapy for Intervention of Experimental Leishmaniasis via Amphotericin B Loaded Solid Lipid Nanoparticles

Jain, Vineet; Gupta, Annie; Pawar, V K; Asthana, Shalini; Jaiswal, A K; Dube, Anuradha; Chourasia, M K (2014)

Solid lipid nanoparticles (SLNs) have emerged as an excellent substitute over polymeric nanoparticles and when incorporated with chitosan which activates the macrophage to impart an immune response, produces excellent ...
4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells

Maurya, C K; Singh, Rohit; Jaiswal, Natasha; Venkateswarlu, K; Narender, Tadigoppula; Tamrakar, A K (2014)

The 4-Hydroxyisoleucine (4-HIL), an unusual amino acid isolated from the seeds of Trigonella foenum-graecum was investigated for the metabolic effects to ameliorate free fatty acid-induced insulin resistance in skeletal ...
Ethanolic extract of Coelogyne cristata Lindley (Orchidaceae) and its compound coelogin promote osteoprotective activity in ovariectomized estrogen deficient mice

Sharma, Chetan; Mansoori, M N; Dixit, Manisha; Shukla, Priyanka; Kumari, Tejaswita; Bhandari, S P S; Narender, T; Singh, Divya; Aryaa, K R (2014)

Coelogyne cristata Lindley (CC) family Orchidaceae is an Indian medicinal plant used for the treatment of fractured bones in folk- tradition of Kumaon region, Uttarakhand, India. In continuation of our drug discovery ...
One-pot Synthesis of Highly Fluorescent Pyrido[1,2-a]indole Derivatives via C-H/N-H Activation: Photophysical Investigations and Application in Cell Imaging

Samala, Srinivas; Pallavi, Pragyan; Kumar, Ravi; Arigela, R K; Singh, Gajendra; Ampapathi, R S; Priya, Amulya; Datta, Sunando; Patra, Abhijit; Kundu, Bijoy (2014)

We describe a simple strategy for the synthesis of strongly fluorescent pyridoindoles by Pd catalyzed oxidative annulations of internal alkynes with C-3 functionalized indoles via C-H/N-H bond activation in a one-pot tandem ...
β-Cyclodextrin Catalysed C-C Bond Formation via C(sp3)-H Functionalization of 2-Methyl azaarenes with Diones in aqueous medium

Kumar, Atul; Shukla, R D (2015)

First β-cyclodextrin catalysed C(sp3)-H functionalization of 2-alkyl-azaarenes with homocyclic as well as heterocyclic diones in water has been developed. This bio- mimetic catalyst oriented methodology provides a sustainable ...
Effect of homeopathic medicine Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats

Hanif, Kashif; Kumar, Manoj; Singh, Neetu; Shukla, Rakesh (2015)

Background: Lycopodium clavatum (Lyc) is a widely used homeopathic medicine for the liver, urinary and digestive disorders. Recently, Acetyl Cholinesterase (AchE) inhibitory activity has been found in Lyc alkaloid extract, ...
Iron nitrate/TEMPO is a superior homogenous catalyst for aerobic oxidation of primary alcohols to nitriles in air

Dighe, S U; Chowdhury, Deepan; Batra, Sanjay (2014)

A highly practical one‐step facile synthesis of aromatic, heteroaromatic, allylic and aliphatic nitriles from primary alcohols catalysed by ferric nitrate (Fe(NO3)3.9H2O) in the presence of TEMPO, aqueous ammonia and air ...
Enhanced immunoprotective effects by anti-IL17 antibody translates to improved skeletal parameters under estrogen deficiency compared to anti- RANKL and anti-TNFα antibodies

Tyagi, A M; Mansoori, M N; Srivastava, Kamini; Khan, M P; Kureel, Jyoti; Dixit, Manisha; Shukla, Priyanka; Trivedi, Ritu; Chattopadhyay, Naibedya; Singh, Divya (2014)

Activated T cell has a key role in the interaction between bone and immune system. T cells produce pro-inflammatory cytokines including, RANKL, TNF-α and IL-17, all of which augment osteoclastogenesis. RANKL and TNF- are ...
Reuse of laboratory animals in experiments: A statistical approach

Mishra, Akansha; Srivastava, Richa; Ahmad, Ishbal; Srivastava, A K; Srivastava, Mukesh (2014)

Background: Large numbers of animals are used in the screening of drug experiments in search of an active lead compound. Oral glucose tolerance test (OGTT) studies are most popular to identify the anti-hyperglycemic ...
Oligomerization of coronin: Implication on actin filament length in Leishmania

Srivastava, Rashmi; Kajuluri, L P; Pathak, Neelam; Gupta, C M; Sahasrabuddhe, A A (2015)

Coronin proteins bind with actin filaments and participate in regulation of actin-dependent processes. These proteins contain a coiled-coil domain at their C-terminus, which is responsible for their dimeric or trimeric ...
A rapid and sensitive LC-MS/MS analysis of diapocynin in rat plasma to investigate in-vitro and in-vivo pharmacokinetics

Chandasana, Hardik; Chhonker, Y S; Bala, Veenu; Prasad, Y D; Sharma, V L; Bhatta, R S (2014)

Natural products have been used traditionally for the treatment and prevention of diseases. Diapocynin is the analogue of the naturally occurring apocynin, a well-known constituent of the Picrorhiza kurroa. It has antioxidant ...
Genetically engineered flavonol enriched tomato fruit modulates chondrogenesis to increase bone length in growing animals

Choudhary, Dharmendra; Pandey, Ashutosh; Adhikary, Sulekha; Ahmad, Naseer; Bhatia, Chitra; Bhambhani, Sweta; Trivedi, P K; Trivedi, Ritu (2016)

Externally visible body and longitudinal bone growth is a result of proliferation of chondrocytes. In growth disorder, there is delay in the age associated increase in height. The present study evaluates the effect of ...
A twinfilin-like protein coordinates karyokinesis by influencing mitotic spindle elongation and DNA replication in Leishmania

Kumar, Gaurav; Kajuluri, L P; Gupta, C M; Sahasrabuddhe, A A (2016)

Twinfilin is an evolutionarily conserved actin-binding protein, which regulates actin-dynamics in eukaryotic cells. Homologs of this protein have been detected in the genome of various protozoan parasites causing diseases ...
EVALUATION OF ANTIDYSLIPIDEMIC EFFECT OF MANGIFERIN AND AMAROGENTIN FROM SWERTIA CHIRAYITA EXTRACT IN HFD INDUCED CHARLES FOSTER RAT MODEL AND THEIR DOCKING STUDIES

Asthana, R K; Gupta, Rasna; Agrawal, Nidhi; Srivastava, Atul; Chaturvedi, Upma; Kannojiya, Sanjeev; Khanna, A K; Bhatia, Gitika; Sharma, V L (2014)

In continuation of our research programs on bio evaluation of medicinal plants in India, we have investigated antidyslipidemic and antioxidant potential of Swertia chirayita (SC) plant, a potent antidiabetic and its ...
Linearization of carbohydrate derived polycyclic frameworks

Singh, Priyanka; Panda, Gautam (2014)

We report an easy access to carbohydrate derived diverse tricyclic skeletons which could be beneficial for exploring polyfunctionalized chiral alicycles. The key reaction to assemble sugar fused tricyclic core is intermolecular ...
Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I

Yadav, Nisha; Khanam, Taran; Shukla, Ankita; Rai, Niyati; Hajela, Kanchan; Ramachandran, Ravishankar (2015)

DNA ligases are critical players of DNA metabolism in all organisms. NAD+-dependent DNA ligases (LigA) found exclusively in bacteria and certain entomopoxviruses are drawing increasing attention as therapeutic targets as ...
Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6- Gingerol in cervical cancer cells

Rastogi, Namrata; Duggal, Shivali; Singh, S K; Porwal, Konica; Srivastava, V K; Maurya, Rakesh; Bhatt, M L B; Mishra, D P (2015)

Human papilloma virus (HPV) expressing E6 and E7 oncoproteins, is known to inactivate the tumor suppressor p53 through proteasomal degradation in cervical cancers. Hence, a possible approach to p53 reactivation and induction ...
Sulphur mobilisation for [Fe-S] cluster assembly by the essential SUF pathway in the Plasmodium falciparum apicoplast and its inhibition

Charan, Manish; Nidhi; Kumar, Bijay; Srivastava, Kumkum; Siddiqi, M I; Habib, Saman (2014)

The plastid of the malaria parasite- the apicoplast is essential for parasite survival. It houses several pathways of bacterial origin that are considered as attractive sites for drug intervention. Among these is the SUF ...
A Rapid Analytical Method for Characterization and Simultaneous Quantitative Determination of Phytoconstituents in Piper betle landraces Using UPLC-ESI-MS/MS

Pandey, Renu; Chandra, Preeti; Srivastva, Mukesh; Arya, K R; Shukla, P K; Kumar, Brijesh (2014)

A rapid ultra performance liquid chromatography electrospray ionisation tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed and validated for identification and characterization of phytoconstituents with ...

Now showing items 101-120 of 1288

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